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Desmethyl Erlotinib
CAS No. 183321-86-0
Desmethyl Erlotinib ( CP-473420, OSI-774 )
Catalog No. M12830 CAS No. 183321-86-0
OSI-420 is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 123 | In Stock |
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| 2MG | 67 | In Stock |
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| 5MG | 111 | In Stock |
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| 10MG | 188 | In Stock |
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| 25MG | 332 | In Stock |
|
| 50MG | 486 | In Stock |
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| 100MG | 704 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDesmethyl Erlotinib
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NoteResearch use only, not for human use.
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Brief DescriptionOSI-420 is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).
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DescriptionOSI-420 is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).
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In Vitro——
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In VivoDesmethyl Erlotinib exhibits t1/2 of 11.96±2.01 h in a pharmacokinetic study in Wistar rats.
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SynonymsCP-473420, OSI-774
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR
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Research Area——
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Indication——
Chemical Information
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CAS Number183321-86-0
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Formula Weight379.41
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Molecular FormulaC21H21N3O4
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Purity>98% (HPLC)
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SolubilityDMSO:83 mg/mL warmed (199.58 mM);Ethanol:<1 mg/mL;Water:<1 mg/Ml
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SMILESCOCCOC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCO
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Moyer JD, et al. Cancer Res. 1997, 57(21), 4838-4848.
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