VCE-004.3( VCE004.3 )

Catalog No. M12799 CAS No. 1818428-14-6

COA

Datasheet

HNMR

HPLC

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Product Name

VCE-004.3
Note

Research use only, not for human use.
Brief Description

VCE-004.3 (VCE004.3) is a novel semi-synthetic cannabidiol derivative behaving as a dual PPARγ/CB2 agonist and CB1 receptor modulator.
Description

VCE-004.3 (VCE004.3) is a novel semi-synthetic cannabidiol derivative behaving as a dual PPARγ/CB2 agonist and CB1 receptor modulator, binds and activates PPARγ (IC50=3.5 uM) and CB2 receptors (pKi=6.69) and antagonizes CB1 receptor (pKi=5.61); binds to an alternative site at the PPARγ ligand-binding pocket (LBP); VCE-004.3 inhibits collagen gene transcription and synthesis and prevents TGFβ-induced fibroblast migration and differentiation to myofibroblasts; VCE-004.3 prevents skin fibrosis, myofibroblast differentiation and ERK1/2 phosphorylation in bleomycin-induced skin fibrosis; reduces mast cell degranulation, macrophage activation, T lymphocytes infiltration, and the expression of inflammatory and profibrotic factors.
In Vitro

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In Vivo

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Synonyms

VCE004.3
Pathway

GPCR/G Protein
Target

Cannabinoid Receptor
Recptor

Cannabinoid Receptor
Research Area

——
Indication

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CAS Number

1818428-14-6
Formula Weight

413.602
Molecular Formula

C26H39NO3
Purity

>98% (HPLC)
Solubility

——
SMILES

CCCCCC1=C(C(=C(C(=O)C1=O)C2C=C(CCC2C(=C)C)C)O)NCCCCC
Chemical Name

(1'R,6'R)-6-hydroxy-3'-methyl-4-pentyl-3-(pentylamino)-6'-(prop-1-en-2-yl)-[1,1'-bi(cyclohexane)]-2',3,6-triene-2,5-dione

1. Del Rio C, et al. Br J Pharmacol. 2018 Jul 22. doi: 10.1111/bph.14450.

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