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LEM-14
CAS No. 1814881-70-3
LEM-14( LEM14 | LEM 14 | LEM-14 )
Catalog No. M12786 CAS No. 1814881-70-3
LEM-14 is a specific inhibitor of histone lysine methyltransferase NSD2 (MMSET/WHSC1) with in vitro IC50 of 132 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 104 | In Stock |
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| 5MG | 98 | In Stock |
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| 10MG | 159 | In Stock |
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| 25MG | 259 | In Stock |
|
| 50MG | 365 | In Stock |
|
| 100MG | 492 | In Stock |
|
| 200MG | 643 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLEM-14
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NoteResearch use only, not for human use.
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Brief DescriptionLEM-14 is a specific inhibitor of histone lysine methyltransferase NSD2 (MMSET/WHSC1) with in vitro IC50 of 132 uM.
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DescriptionLEM-14 is a specific inhibitor of histone lysine methyltransferase NSD2 (MMSET/WHSC1) with in vitro IC50 of 132 uM, and that is inactive against the closely related NSD1 and NSD3.
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In Vitro——
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In Vivo——
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SynonymsLEM14 | LEM 14 | LEM-14
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorHMTase
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Research Area——
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Indication——
Chemical Information
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CAS Number1814881-70-3
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Formula Weight478.567
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Molecular FormulaC25H26N4O4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (104.48 mM)
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SMILESO=C1C(C2=C(CCCC2)S3)=C3N=C(CN4CCN(C([C@@H](CC5=C6C=CC=C5)OC6=O)=O)CC4)N1
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Chemical Name(R)-2-((4-(1-oxoisochromane-3-carbonyl)piperazin-1-yl)methyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shen Y, et al. Biochem Biophys Res Commun. 2018 Nov 21. pii: S0006-291X(18)32443-4.
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