LYS228( LYS-228 | LYS 228 )

Catalog No. M12777 CAS No. 1810051-96-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

LYS228
Note

Research use only, not for human use.
Brief Description

LYS228 is a novel potent monobactam that shows potent activity against carbapenem-resistant isolates of Enterobacteriaceae with MIC90 of 2 ug/ml.
Description

LYS228 is a novel potent monobactam that shows potent activity against carbapenem-resistant isolates of Enterobacteriaceae with MIC90 of 2 ug/ml; LYS228 is stable against Metallo-β-lactamases (MBLs), and shows small or no MIC shifts for most SBLs (serine β-lactamases), including CTX-Ms, KPCs and OXA-types.Bacterial Infection Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

LYS-228 | LYS 228
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

Infection
Indication

Bacterial Infection

CAS Number

1810051-96-7
Formula Weight

518.472
Molecular Formula

C16H18N6O10S2
Purity

>98% (HPLC)
Solubility

——
SMILES

C1CC1(C(=O)O)ON=C(C2=CSC(=N2)N)C(=O)NC3C(N(C3=O)S(=O)(=O)O)CN4CCOC4=O
Chemical Name

1-((((Z)-1-(2-aminothiazol-4-yl)-2-oxo-2-(((3S,4R)-2-oxo-4-((2-oxooxazolidin-3-yl)methyl)-1-sulfoazetidin-3-yl)amino)ethylidene)amino)oxy)cyclopropane-1-carboxylic acid

1. Reck F, et al. Bioorg Med Chem Lett. 2018 Feb 15;28(4):748-755.

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