Bupivacaine hydrochloride

Research use only, not for human use.

Bupivacaine hydrochloride binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells.

Bupivacaine hydrochloride binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, used for treating cardiac arrhythmias. Bupivacaine Hydrochloride is a local anaesthetic drug belonging to the amino amide group.(In Vitro):Bupivacaine hydrochloride inhibits NMDA receptor-mediated synaptic transmission in the dorsal horn of the spinal cord, an area critically involved in central sensitization.Bupivacaine hydrochloride influences the voltage dependency of channel activation and steady-state inactivation by shifting the membrane potential of half-maximal activation/inactivation toward somewhat more negative membrane potentials. In their inactivated state, SCN5A channels are slightly sensitive toward Bupivacaine hydrochloride IC50=2.18±0.16 μM.Bupivacaine hydrochloride reversibly inhibits the SK2 channel in a dose-dependent manner with the IC 50 of 16.5 μM.

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GPCR/G Protein

Prostaglandin Receptor

PGE2| Sodium Channel

Neurological Disease

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18010-40-7

324.89

C18H28N2O·HCl

>98% (HPLC)

Ethanol: 65 mg/mL (200.06 mM); Water: 23 mg/mL (70.79 mM); DMSO: 65 mg/mL (200.06 mM)

Cl.CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C

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(-20℃)

With Ice Pack

≥ 2 years