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MZ1
CAS No. 1797406-69-9
MZ1( MZ-1 | MZ 1 )
Catalog No. M12715 CAS No. 1797406-69-9
MZ1 is a PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers, induces degradation of the BET bromodomain BRD4.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 155 | In Stock |
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| 10MG | 202 | In Stock |
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| 25MG | 310 | In Stock |
|
| 50MG | 398 | In Stock |
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| 100MG | 579 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameMZ1
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NoteResearch use only, not for human use.
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Brief DescriptionMZ1 is a PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers, induces degradation of the BET bromodomain BRD4.
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DescriptionMZ1 is a PROTAC that tethers JQ1 to a ligand for the E3 ubiquitin ligase VHL, triggers, induces degradation of the BET bromodomain BRD4; induces reversible, long-lasting, and unexpectedly selective removal of BRD4 over BRD2 and BRD3.
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In VitroWestern Blot Analysis Cell Line:LS174t cells Concentration:0, 100, and 250 nM Incubation Time:24 hours Result:Led to complete degradation of BRD4 protein, whereas the expression of BRD4 mRNA was not reduced.
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In Vivo——
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SynonymsMZ-1 | MZ 1
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PathwayPROTACs
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TargetPROTAC
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RecptorPROTAC
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Research Area——
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Indication——
Chemical Information
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CAS Number1797406-69-9
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Formula Weight1002.644
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Molecular FormulaC49H60ClN9O8S2
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Purity>98% (HPLC)
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SolubilityDMSO : 25 mg/mL 24.93 mM; H2O : < 0.1 mg/mL
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SMILESO=C([C@H]1N(C([C@@H](NC(COCCOCCOCCNC(C[C@H]2C3=NN=C(C)N3C4=C(C(C)=C(C)S4)C(C5=CC=C(Cl)C=C5)=N2)=O)=O)C(C)(C)C)=O)CCC1)NCC6=CC=C(C7=C(C)N=CS7)C=C6
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Chemical Name(2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zengerle M, et al. ACS Chem Biol. 2015 Aug 21;10(8):1770-7.
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