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SYM-2206
CAS No. 173952-44-8
SYM-2206( SYM2206 )
Catalog No. M12640 CAS No. 173952-44-8
An allosteric, non-competitive antagonist of the AMPA receptor with IC50 of 2.8 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
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| 5MG | 77 | In Stock |
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| 10MG | 123 | In Stock |
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| 25MG | 261 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSYM-2206
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NoteResearch use only, not for human use.
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Brief DescriptionAn allosteric, non-competitive antagonist of the AMPA receptor with IC50 of 2.8 uM.
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DescriptionAn allosteric, non-competitive antagonist of the AMPA receptor with IC50 of 2.8 uM; acts allosterically at the same regulatory site as GYKI 52466 and 53655 and other benzodiazepines but does not bind to the central diazepine binding site; shows selectivity for AMPA relative to kainate receptor sub-types.Epilepsy Discontinued.
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In Vitro——
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In Vivo——
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SynonymsSYM2206
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PathwayMembrane Transporter/Ion Channel
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TargetiGluR
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RecptoriGluR
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Research AreaNeurological Disease
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IndicationEpilepsy
Chemical Information
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CAS Number173952-44-8
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Formula Weight366.4137
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Molecular FormulaC20H22N4O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(N1N=C(C2=CC=C(N)C=C2)C3=CC(OCO4)=C4C=C3C1C)NCCC
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Chemical Name1,3-Dioxolo[4,5-g]phthalazine-6(5H)-carboxamide, 8-(4-aminophenyl)-5-methyl-N-propyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Pei XF, et al. Bioorg Med Chem Lett. 1999 Feb 22;9(4):539-42.
2. Li P, et al. Nature. 1999 Jan 14;397(6715):161-4.
3. Behr J, et al. Eur J Neurosci. 2002 Sep;16(5):861-7.
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