I-BRD9

Research use only, not for human use.

The first selective cellular chemical probe for BRD9 with pIC50 of 7.3.

The first selective cellular chemical probe for BRD9 with pIC50 of 7.3; displays 700-fold selectivity over the BET family and 200-fold over the highly homologous BRD7; decreases cell proliferation, G1-arrest and apoptosis in rhabdoid tumor cells; shows synergistic inhibitory effects on cell proliferation combined with doxorubicin or carboplatin.

I-BRD9 (10 μM, 6 h) has a regulation role in cancer and immunology pathways.I-BRD9 (10 μM) has high BRD9 affinity and excellent broader bromodomain selectivity.I-BRD9 (10 μM) has affinity for BRD9 (TR-FRET), BRD4 BD1 (TR-FRET) and BRD9 NanoBRET with pIC50 values of 7.3 μM, 5.3 μM and 6.8 μM.I-BRD9 (10 μM) has high aqueous solubility (CLND) with 359 μM.I-BRD9 (10 μM) displays >625 fold selectivity in binding with endogenous BRD9 against BET family member BRD3 in HUT-78 cell lysate. RT-PCR Cell Line:Kasumi-1 cells Concentration:10 μM Incubation Time:6 h Result:Showed 4 genes (CLEC1, 62 DUSP6, 63 FES64 and SAMSN165) that were strongly down-regulated and not by I-BET151.

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I-BRD9 | I-BRD-9 | I-BRD 9

Chromatin/Epigenetic

Bromodomain

BRD4|BRD9

Other Indications

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1714146-59-4

497.5536

C22H22F3N3O3S2

>98% (HPLC)

DMSO: 15.5 mg/mL

N=C(C(S1)=CC2=C1C(C3=CC=CC(C(F)(F)F)=C3)=CN(CC)C2=O)NC(CC4)CCS4(=O)=O

Thieno[3,2-c]pyridine-2-carboximidamide, 5-ethyl-4,5-dihydro-4-oxo-N-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-7-[3-(trifluoromethyl)phenyl]-

(-20℃)

With Ice Pack

≥ 2 years