SC-236( SC236 | SC58236 )

Catalog No. M12605 CAS No. 170569-86-5

SC-236 (SC58236) is a potent, selective, orally active inhibitor of COX-2 with IC50 of 10 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	44	In Stock
5MG	39	In Stock
10MG	58	In Stock
25MG	117	In Stock
50MG	206	In Stock
100MG	306	In Stock
200MG	442	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

SC-236
Note

Research use only, not for human use.
Brief Description

SC-236 (SC58236) is a potent, selective, orally active inhibitor of COX-2 with IC50 of 10 nM.
Description

SC-236 (SC58236) is a potent, selective, orally active inhibitor of COX-2 with IC50 of 10 nM; displays >1,700-fold selectivity over COX-1 (IC50=17.8 uM); exhibits anti-inflammatory properties and potent antimetastatic activity both in vitro and in vivo.
In Vitro

Western Blot Analysis Cell Line:vECs.Concentration:15 μM Incubation Time:30 min.Result:Showd significant reduction in COX-2 level and increase in IκBα level, thus preventing ALSS-induced NFκB activation and inflammation in vECs.Western Blot Analysis Cell Line:COS 7 cells.Concentration:3 and 10 μM.Incubation Time:18 h (combined with 15d-PGJ2).Result:Acted in a concentration-dependent manner as a PPARγ agonist.
In Vivo

Animal Model:Seventy-six male adult Wistar rats weighing 200-220 g (CCl4-treated).Dosage:6 mg/kg.Administration:Orally, 3 times per week.Result:A marked induction of COX-2 protein expression was detected by immunohistochemistry in the liver of CCl4-treated rats.Significantly reduced the degree of liver fibrosis.Dramatically suppressed α-SMA expression in CCl4-treated rats.
Synonyms

SC236 | SC58236
Pathway

Chromatin/Epigenetic
Target

COX
Recptor

COX
Research Area

——
Indication

——

Chemical Information

CAS Number

170569-86-5
Formula Weight

401.8
Molecular Formula

C16H11ClF3N3O2S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (248.89 mM)
SMILES

O=S(C1=CC=C(N2N=C(C(F)(F)F)C=C2C3=CC=C(Cl)C=C3)C=C1)(N)=O
Chemical Name

4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Penning TD, et al. J Med Chem. 1997 Apr 25;40(9):1347-65. 2. Lee A, et al. Cancer Res. 2006 Apr 15;66(8):4378-84. 3. Roche-Nagle G, et al. Br J Cancer. 2004 Jul 19;91(2):359-65.

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