SGC-707

Research use only, not for human use.

SGC-707 is a potent, selective and cell-active allosteric inhibitor of PRMT3 (IC50=31 nM; Kd=53 nM).

SGC-707 is a potent, selective and cell-active allosteric inhibitor of PRMT3 (IC50=31 nM; Kd=53 nM); shows outstanding selectivity against 31 other methyltransferases and more than 250 non-epigenetic targets; active in cells, also bioavailable and suitable for animal studies.

Cell Viability Assay Cell Line:HEK293 and A549 cells Concentration:0-10 μM Incubation Time:6 hours Result:Stabilized PRMT3 in both HEK293 and A549 cells with EC50 values of 1.3 μM and 1.6 μM, respectively.

Animal Model:Western-type diet-fed LDL (lipoprotein) receptor knockout mice Dosage:10 mg/kg Administration:Intraperitoneal injection; 10 mg/kg; 3 times per week; 3 weeks Result:Exhibited 50% lower liver triglyceride stores as well as 32% lower plasma triglyceride levels.

SGC 707 | SGC707

Chromatin/Epigenetic

HMTase

PRMT3

Other Indications

——

1687736-54-4

298.3397

C16H18N4O2

>98% (HPLC)

10 mM in DMSO

O=C(NCC(N1CCCC1)=O)NC2=CC3=C(C=NC=C3)C=C2

Urea, N-6-isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-

(-20℃)

With Ice Pack

≥ 2 years