Cart
sales@molnova.com
EPZ6438
CAS No. 1403254-99-8
EPZ6438( Tazemetostat )
Catalog No. M11686 CAS No. 1403254-99-8
EPZ-6438 is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 58 | In Stock |
|
| 2MG | 29 | In Stock |
|
| 5MG | 46 | In Stock |
|
| 10MG | 64 | In Stock |
|
| 25MG | 80 | In Stock |
|
| 50MG | 86 | In Stock |
|
| 100MG | 144 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 375 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameEPZ6438
-
NoteResearch use only, not for human use.
-
Brief DescriptionEPZ-6438 is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays.
-
DescriptionEPZ-6438 is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs.
-
In Vitro——
-
In Vivo——
-
SynonymsTazemetostat
-
PathwayChromatin/Epigenetic
-
TargetHMTase
-
RecptorEZH2| EZH2
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number1403254-99-8
-
Formula Weight572.74
-
Molecular FormulaC34H44N4O4
-
Purity>98% (HPLC)
-
SolubilityDMSO: 9 mg/mL (15.71 mM)
-
SMILESO=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(CC)C4CCOCC4)=C1C)NCC5=C(C)C=C(C)NC5=O
-
Chemical NameN-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Knutson SK, et al. Proc Natl Acad Sci U S A. 2013, 110(19), 7922-7927.
molnova catalog
related products
-
MM-589
A highly potent, cell-permeable inhibitor of WDR5-MLL interaction with IC50 of 0.9 nM, Ki of <1 nM.
-
WDR5 WIN site inhibi...
WDR5 WIN site inhibitor C6 is a potent, specific WIN (WDR5 interaction) site inhibitor of WDR5 with Kd of 0.1 nM.
-
EZM 2302
EZM 2302 (EZM2302, GSK 3359088)?is a potent, selective, orally available arginine methyltransferase CARM1 inhibitor with IC50 of 6 nM.
