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JKA3 inhibitor 31
CAS No. 1637749-82-6
JKA3 inhibitor 31( —— )
Catalog No. M12470 CAS No. 1637749-82-6
JKA3 inhibitor 31 is a highly potent, selective, reversible, covalent JAK3 inhibitor with IC50 of 49 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameJKA3 inhibitor 31
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NoteResearch use only, not for human use.
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Brief DescriptionJKA3 inhibitor 31 is a highly potent, selective, reversible, covalent JAK3 inhibitor with IC50 of 49 nM.
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DescriptionJKA3 inhibitor 31 is a highly potent, selective, reversible, covalent JAK3 inhibitor with IC50 of 49 nM, shows no activity against other JAK kinases; also inhibits BLK, ERB-B4 and ITK with IC50 of 22 nM, 44 nM and 221 nM, respectively.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetJAK
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RecptorJAK
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Research Area——
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Indication——
Chemical Information
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CAS Number1637749-82-6
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Formula Weight288.31
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Molecular FormulaC17H12N4O
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name3-(3-(1H-indazol-4-yl)phenyl)-2-cyanoacrylamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. London N, et al. Nat Chem Biol. 2014 Dec;10(12):1066-72.
2. Clark JD, et al. J Med Chem. 2014 Jun 26;57(12):5023-38.
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