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SF0166
CAS No. 1621332-91-9
SF0166( SF 0166 | SF-0166 )
Catalog No. M12385 CAS No. 1621332-91-9
SF0166 is a topically administered αvβ3 integrin antagonist, inhibits integrin-ligand interactions with IC50 of 0.6 nM to 13 nM for human αvβ3, αvβ6, and αvβ8.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1503 | In Stock |
|
| 50MG | 3042 | In Stock |
|
| 100MG | 4140 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSF0166
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NoteResearch use only, not for human use.
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Brief DescriptionSF0166 is a topically administered αvβ3 integrin antagonist, inhibits integrin-ligand interactions with IC50 of 0.6 nM to 13 nM for human αvβ3, αvβ6, and αvβ8.
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DescriptionSF0166 is a topically administered αvβ3 integrin antagonist, inhibits integrin-ligand interactions with IC50 of 0.6 nM to 13 nM for human αvβ3, αvβ6, and αvβ8; inhibits cellular adhesion to vitronectin across human, rat, rabbit, and dog cell lines with IC50 of 7.6 pM-76 nM; significantly decreases neovascularization in the oxygen-induced retinopathy mouse models.Other Indication Phase 2 Clinical.
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In Vitro——
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In VivoAnimal Model:Female 129SVE newborn mice with oxygen-induced retinopathy (OIR) modelsDosage:5% SF0166 Administration:Bilateral eye topical drip 5% SF0166 Result:Reduced new blood vessel formation.
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SynonymsSF 0166 | SF-0166
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PathwayCell Cycle/DNA Damage
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TargetIntegrin
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RecptorIntegrin
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number1621332-91-9
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Formula Weight475.497
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Molecular FormulaC23H27F2N5O4
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(O)C[C@@H](C1=CC=C(OC(F)F)N=C1)N2CCN(CCCC3=NC4=C(CCCN4)C=C3)C2=O
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Chemical Name(S)-3-(6-(difluoromethoxy)pyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Lifitegrast sodium
Lifitegrast sodium (SAR-1118-023 sodium) is a small molecule integrin antagonist that inhibits T cell-mediated inflammation by blocking the binding of two important cell surface proteins (lymphocyte function-associated antigen 1 and intercellular adhesion molecule 1), which reduces inflammation of the ocular surface, and may be used in the study of dry eye.
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Echistatin, α1 isofo...
Potent irreversible αVβ3 integrin antagonist (Ki = 0.27 nM). Disrupts attachment of osteoclasts to bone and inhibits bone reabsorption (IC50 = 0.1 nM). Prevents ADP-induced platelet aggregation via inhibition of glycoprotein IIb/IIIa (GpIIb/IIIa, αIIbβ3) receptors (IC50 = 30 nM) in vitro.
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CWHM-12
A novel active RGD peptidomimetic inhibitor of αv integrin with IC50s of 1.8/0.8/61/1.5/0.2 nM for αvβ1/αvβ3/αvβ5/αvβ6/αvβ8; no inhibition on αIIbβ3, α2β1 and α10β1 (>50 uM).
