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A 286982
CAS No. 280749-17-9
A 286982( —— )
Catalog No. M24194 CAS No. 280749-17-9
A 286982 is an inhibitor that blocks the integrin-ligand interaction between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 70 | In Stock |
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| 2MG | 41 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 104 | In Stock |
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| 25MG | 211 | In Stock |
|
| 50MG | 343 | In Stock |
|
| 100MG | 511 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameA 286982
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NoteResearch use only, not for human use.
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Brief DescriptionA 286982 is an inhibitor that blocks the integrin-ligand interaction between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1.
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DescriptionA 286982 is an inhibitor that blocks the integrin-ligand interaction between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1.
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In VitroA-286982 binds to the I domain allosteric site (IDAS). The allosteric ICAM inhibition such as this would be expected to exhibit the unsurmountable competition we have observed for A-286982 as a result of the passage of this allostery through the A-286982 binding site in its transmission from the β subunit I-like domain to the α subunit ICAM binding site.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetIntegrin
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RecptorLFA-1|ICAM-1
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Research Area——
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Indication——
Chemical Information
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CAS Number280749-17-9
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Formula Weight453.6
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Molecular FormulaC24H27N3O4S
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Purity>98% (HPLC)
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SolubilityDMSO:<45.35 mg/mL (100mM)
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SMILESO=C(N1CCN(C(C)=O)CC1)/C=C/C2=CC=C(SC3=CC=CC=C3C(C)C)C([N+]([O-])=O)=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Liu G, Link JT, Pei Z, et al. Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead. J Med Chem. 2000;43(21):4025-4040. doi:10.1021/jm0002782
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