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Home - Products - Cell Cycle/DNA Damage - DNA/RNA Synthesis - TH-588

TH-588

CAS No. 1609960-31-7

TH-588( TH588 )

Catalog No. M12322 CAS No. 1609960-31-7

A potent and selective inhibitor of MTH1 protein with IC50 of 5 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 60 In Stock
2MG 33 In Stock
5MG 54 In Stock
10MG 79 In Stock
25MG 122 In Stock
50MG 203 In Stock
100MG 381 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    TH-588
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective inhibitor of MTH1 protein with IC50 of 5 nM.
  • Description
    A potent and selective inhibitor of MTH1 protein with IC50 of 5 nM; shows no relevant inhibition for MTH2,NUDT5, NUDT12,NUDT14,NUDT16 and other proteinswith known nucleoside triphosphate pyrophosphatase activity; causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.
  • In Vitro
    Cell Viability Assay Cell Line:U2OS, HeLa, MDA-MB-231, MCF-7, SW480, SW620, VH10, HDFn cells Concentration:2, 4, 6, 8, 10 μM Incubation Time:7-10 days Result:Selectively and effectively killed U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC50s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM, but was less toxic to several primary or immortalized cells.
  • In Vivo
    Animal Model:5-6 weeks female SCID mice (SW480 xenograft cancer model)Dosage:30 mg/kg Administration:Subcutaneous injection; once daily for 35 days Result:Reduced tumour growth in SW480 xenograft cancer model.
  • Synonyms
    TH588
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    MTH1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1609960-31-7
  • Formula Weight
    295.1672
  • Molecular Formula
    C13H12Cl2N4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 16 mg/mL
  • SMILES
    NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC3CC3)=N1
  • Chemical Name
    2,4-Pyrimidinediamine, N4-cyclopropyl-6-(2,3-dichlorophenyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gad H, et al. Nature. 2014 Apr 10;508(7495):215-21. 2. Wang M, et al. Sci Rep. 2017 Jan 11;7:40557. 3. Warpman Berglund U, et al. Ann Oncol. 2016 Dec;27(12):2275-2283.
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