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AMG319
CAS No. 1608125-21-8
AMG319( AMG-319 | AMG 319 )
Catalog No. M12313 CAS No. 1608125-21-8
AMG319 (AMG-319) is a potent and selective PI3Kδ inhibitor with biochemical IC50 of 18 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 70 | In Stock |
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| 2MG | 40 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 107 | In Stock |
|
| 25MG | 227 | In Stock |
|
| 50MG | 380 | In Stock |
|
| 100MG | 554 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAMG319
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NoteResearch use only, not for human use.
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Brief DescriptionAMG319 (AMG-319) is a potent and selective PI3Kδ inhibitor with biochemical IC50 of 18 nM.
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DescriptionAMG319 (AMG-319) is a potent and selective PI3Kδ inhibitor with biochemical IC50 of 18 nM, displays >80-fold selectivity over PI3Kα/β/γ (IC50=3300/2700/850 nM); exhibits an IC50 of 16 nM in human whole blood assay (HWB), excellent selectivity over a large panel of protein kinases; inhibits anti-IgM induced AKT phosphorylation (Ser473) in mouse B cells with IC50 of 1.5 nM, inhibits anti-IgM/CD40L-induced B cell proliferation with IC50 of 8.6 nM; exhibits in vivo efficacy in rodent disease models of inflammation.Solid Tumors Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsAMG-319 | AMG 319
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3Kα|PI3Kβ|PI3Kγ|PI3Kδ
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Research AreaCancer
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IndicationSolid Tumors
Chemical Information
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CAS Number1608125-21-8
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Formula Weight385.397
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Molecular FormulaC21H16FN7
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC[C@H](NC1=C2N=CNC2=NC=N1)C3=CC4=CC=C(F)C=C4N=C3C5=NC=CC=C5
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Chemical Name3-Quinolinemethanamine, 7-fluoro-α-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-, (αS)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cushing TD, et al. J Med Chem. 2015 Jan 8;58(1):480-511.
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