AMG319( AMG-319 | AMG 319 )

Catalog No. M12313 CAS No. 1608125-21-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

AMG319
Note

Research use only, not for human use.
Brief Description

AMG319 (AMG-319) is a potent and selective PI3Kδ inhibitor with biochemical IC50 of 18 nM.
Description

AMG319 (AMG-319) is a potent and selective PI3Kδ inhibitor with biochemical IC50 of 18 nM, displays >80-fold selectivity over PI3Kα/β/γ (IC50=3300/2700/850 nM); exhibits an IC50 of 16 nM in human whole blood assay (HWB), excellent selectivity over a large panel of protein kinases; inhibits anti-IgM induced AKT phosphorylation (Ser473) in mouse B cells with IC50 of 1.5 nM, inhibits anti-IgM/CD40L-induced B cell proliferation with IC50 of 8.6 nM; exhibits in vivo efficacy in rodent disease models of inflammation.Solid Tumors Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

AMG-319 | AMG 319
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3Kα|PI3Kβ|PI3Kγ|PI3Kδ
Research Area

Cancer
Indication

Solid Tumors

CAS Number

1608125-21-8
Formula Weight

385.397
Molecular Formula

C21H16FN7
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

C[C@H](NC1=C2N=CNC2=NC=N1)C3=CC4=CC=C(F)C=C4N=C3C5=NC=CC=C5
Chemical Name

3-Quinolinemethanamine, 7-fluoro-α-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-, (αS)-

1. Cushing TD, et al. J Med Chem. 2015 Jan 8;58(1):480-511.

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