PI3K-IN-1( SAR245409 | Voxtalisib )

Catalog No. M11414 CAS No. 1349796-36-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

PI3K-IN-1
Note

Research use only, not for human use.
Brief Description

PI3K-IN-1 is a potent inhibitor of PI3K.
Description

PI3K-IN-1 is a potent inhibitor of PI3K, extracted from patent WO2012103524 A2 and WO2013147649 A2.(In Vitro):PI3K-IN-1 (25 μM) blocks PI3K/Akt signaling pathways. By using the PI3K inhibitor PI3K-IN-1, TGF-β1 induced transformation into myofibroblast is also inhibited, with relatively reduced expressions of α-SMA, Col-1 and Timp-1.
In Vitro

PI3K-IN-1 (25 μM) blocks PI3K/Akt signaling pathways. By using the PI3K inhibitor PI3K-IN-1, TGF-β1 induced transformation into myofibroblast is also inhibited, with relatively reduced expressions of α-SMA, Col-1 and Timp-1.
In Vivo

——
Synonyms

SAR245409 | Voxtalisib
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

DNA-PK|PI3Kα|PI3Kβ|PI3Kγ|PI3Kδ
Research Area

Cancer
Indication

——

CAS Number

1349796-36-6
Formula Weight

599.6569
Molecular Formula

C31H29N5O6S
Purity

>98% (HPLC)
Solubility

DMSO: 27.5 mg/mL
SMILES

O=C(NC1=CC=C(S(=O)(NC2=NC3=CC=CC=C3N=C2NC4=CC(OC)=CC(OC)=C4)=O)C=C1)C5=CC=C(C)C(OC)=C5
Chemical Name

N-(4-(N-(3-((3,5-dimethoxyphenyl)amino)quinoxalin-2-yl)sulfamoyl)phenyl)-3-methoxy-4-methylbenzamide