LAS195319( LAS-195319 | LAS 195319 )

Catalog No. M12307 CAS No. 1605328-04-8

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HPLC

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Product Name

LAS195319
Note

Research use only, not for human use.
Brief Description

LAS195319 (LAS-195319) is a potent, selective, inhaled PI3Kδ inhibitor with IC50 of 0.5 nM.
Description

LAS195319 (LAS-195319) is a potent, selective, inhaled PI3Kδ inhibitor with IC50 of 0.5 nM, weakly inhibits PI3Kβ and γ (>20-fold), no activity against PI3Kα; inhibits M-CSF induced pAkt (Thr308) in THP-1 cells with IC50 of 2.7 nM; inhibits inflammatory cell infiltration induced by OVA challenge in a Brown Norway rat model.
In Vitro

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In Vivo

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Synonyms

LAS-195319 | LAS 195319
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3K
Research Area

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Indication

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CAS Number

1605328-04-8
Formula Weight

594.654
Molecular Formula

C29H26N10O3S
Purity

>98% (HPLC)
Solubility

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SMILES

CC1=C2C(=O)N(C(=NN2C=C1)C(C)NC3=NC=NC4=C3C(=CN4)C5=C6C=CNC6=CC(=C5)NS(=O)(=O)N)C7=CC=CC=C7
Chemical Name

N-[4-(4-{[(1S)-1-(5-Methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-indol-6-yl]sulfamide

1. Erra M, et al. J Med Chem. 2018 Oct 29. doi: 10.1021/acs.jmedchem.8b00873.

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