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Marimastat

CAS No. 154039-60-8

Marimastat( BB-2516 | TA-2516 )

Catalog No. M12177 CAS No. 154039-60-8

A broad spectrum MMP inhibitor for MMP9/1/2/14/7 with IC50 of 3/5/6/9/13 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 58 In Stock
5MG 81 In Stock
10MG 123 In Stock
25MG 218 In Stock
50MG 355 In Stock
100MG 523 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Marimastat
  • Note
    Research use only, not for human use.
  • Brief Description
    A broad spectrum MMP inhibitor for MMP9/1/2/14/7 with IC50 of 3/5/6/9/13 nM, respectively.
  • Description
    A broad spectrum MMP inhibitor for MMP9/1/2/14/7 with IC50 of 3/5/6/9/13 nM, respectively.Lung Cancer Phase 3 Clinical(In Vitro):Marimastat (BB2516) (1 μM) shows inhibition of vascular outgrowth, and selectively affects angiogenesis.(In Vivo):Animals receiving chemoradiation + Marimastat (BB2516) (8.7 mg/kg) have statistically significant delayed growth, compared to animals receiving chemoradiation alone. Marimastat (BB2516) may work in combination with chemotherapy and radiation to inhibit tumor growth.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BB-2516 | TA-2516
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    MMP
  • Recptor
    MMP-1| MMP-14| MMP-2| MMP-7| MMP-9
  • Research Area
    Cancer
  • Indication
    Lung Cancer

Chemical Information

  • CAS Number
    154039-60-8
  • Formula Weight
    331.4079
  • Molecular Formula
    C15H29N3O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 140 mg/mL
  • SMILES
    O=C(N[C@@H](C(C)(C)C)C(NC)=O)[C@H](CC(C)C)[C@H](O)C(NO)=O
  • Chemical Name
    Butanediamide, N4-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)-, (2S,3R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rasmussen HS, et al. Pharmacol Ther. 1997;75(1):69-75. 2. Sinno M, et al. Stem Cells Dev. 2013 Feb 1;22(3):345-58. 3. Quemener C, et al. Cancer Res. 2007 Jan 1;67(1):9-15.
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