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AD-35
CAS No. 1531586-58-9
AD-35( AD 35 | AD35 )
Catalog No. M12148 CAS No. 1531586-58-9
A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1053 | Get Quote |
|
| 50MG | 2142 | Get Quote |
|
| 100MG | 2790 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameAD-35
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NoteResearch use only, not for human use.
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Brief DescriptionA donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates.
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DescriptionA donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates; markedly attenuates Aβ25-35 injection-induced astrocyte activation, pro-inflammatory cytokines TNF-α and IL-1β release, and memory deficits in vivo; orally active.
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In Vitro——
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In Vivo——
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SynonymsAD 35 | AD35
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PathwayMetabolic Enzyme/Protease
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TargetAChE
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RecptorAChE
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Research Area——
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Indication——
Chemical Information
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CAS Number1531586-58-9
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Formula Weight405.498
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Molecular FormulaC24H27N3O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C1N(CCC2CCN(CC3=NC=CC=C3)CC2)C4(C5=C1C=C(OCO6)C6=C5)CC4
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Chemical Name6'-(2-(1-(pyridin-2-ylmethyl)piperidin-4-yl)ethyl)spiro[cyclopropane-1,5'-[1,3]dioxolo[4,5-f]isoindol]-7'(6'H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Li L, et al. J Alzheimers Dis. 2017;56(4):1403-1417.
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