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Nalfurafine
CAS No. 152657-84-6
Nalfurafine( TRK-820 | TRK820 )
Catalog No. M12134 CAS No. 152657-84-6
Nalfurafine (TRK-820, TRK820) is potent, selective agonist of kappa-opioid receptor with Ki of 3.5 nM, 15-fold less potent for μOR and little affinity for δOR (Ki=53 and 1,200 nM, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 249 | Get Quote |
|
| 5MG | 354 | Get Quote |
|
| 10MG | 527 | Get Quote |
|
| 25MG | 845 | Get Quote |
|
| 50MG | 1143 | Get Quote |
|
| 100MG | 1548 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameNalfurafine
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NoteResearch use only, not for human use.
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Brief DescriptionNalfurafine (TRK-820, TRK820) is potent, selective agonist of kappa-opioid receptor with Ki of 3.5 nM, 15-fold less potent for μOR and little affinity for δOR (Ki=53 and 1,200 nM, respectively).
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DescriptionNalfurafine (TRK-820, TRK820) is potent, selective agonist of kappa-opioid receptor with Ki of 3.5 nM, 15-fold less potent for μOR and little affinity for δOR (Ki=53 and 1,200 nM, respectively); also potently binds to mutant κ(E297K), μ(K303E), κ(E297W) and κ(E297A) with Ki of 10-50 nM; inhibits forskolin-stimulated intracellular cAMP accumulation with IC50 of 0.15 nM, which is 100 fold smaller than that of U69593; produces potent antinociceptive effects in vivo.Other Indication Approved.
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In Vitro——
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In Vivo——
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SynonymsTRK-820 | TRK820
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PathwayEndocrinology/Hormones
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TargetOpioid Receptor
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RecptorOpioid Receptor
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number152657-84-6
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Formula Weight476.5641
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Molecular FormulaC28H32N2O5
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCN(C1CCC2(C3CC4=C5C2(C1OC5=C(C=C4)O)CCN3CC6CC6)O)C(=O)C=CC7=COC=C7
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Chemical Name2-Propenamide, N-[(5α,6β)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]-3-(3-furanyl)-N-methyl-, (2E)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nagase H, et al. Chem Pharm Bull (Tokyo). 1998 Feb;46(2):366-9.
2. Seki T, et al. Eur J Pharmacol. 1999 Jul 2;376(1-2):159-67.
3. Endoh T, et al. Life Sci. 1999;65(16):1685-94.
4. Endoh T, et al. Eur J Pharmacol. 2000 Jan 10;387(2):133-40.
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