BGC20-1531( PGN-1531 | AP 1531 | BGC 20-1531 )

Catalog No. M13079 CAS No. 1962928-26-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BGC20-1531
Note

Research use only, not for human use.
Brief Description

BGC20-1531 (PGN-1531, AP 1531) is a potent, selective prostanoid EP receptor EP antagonist.
Description

BGC20-1531 (PGN-1531, AP 1531) is a potent, selective prostanoid EP receptor EP antagonist, exhibits high affinity at recombinant human EP4 receptors expressed in cell lines (pKB=7.6) and native EP4 receptors in human cerebral and meningeal artery (pKB=7.6-7.8); shows no appreciable affinity at a wide range of other receptors (including other prostanoid receptors), channels, transporters and enzymes (pKi < 5); competitively antagonizes PGE(2)-induced vasodilatation of human middle cerebral (pK(B) 7.8) and meningeal (pK(B) 7.6) arteries in vitro, and PGE(2)-induced increase in canine carotid blood flow in vivo.Migraine Phase 2 Discontinued.
In Vitro

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In Vivo

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Synonyms

PGN-1531 | AP 1531 | BGC 20-1531
Pathway

GPCR/G Protein
Target

Prostaglandin Receptor
Recptor

Prostaglandin Receptor
Research Area

Neurological Disease
Indication

Migraine

CAS Number

1962928-26-2
Formula Weight

529.004
Molecular Formula

C26H25ClN2O6S
Purity

>98% (HPLC)
Solubility

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SMILES

CC1=CC=CC=C1S(=O)(=O)NC(=O)C2=CC(=C(O2)C)COC3=CC=C(C=C3)C4=NC=C(C=C4)OC.Cl
Chemical Name

4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride

1. Maubach KA, et al. Br J Pharmacol. 2009 Jan;156(2):316-27. 2. Antonova M, et al. J Headache Pain. 2011 Oct;12(5):551-9.

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