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Adomeglivant

CAS No. 1488363-78-5

Adomeglivant( LY-2409021 )

Catalog No. M12058 CAS No. 1488363-78-5

A potent, selective, orally active, small-molecule antagonist of human glucagon receptor with Ki of 6.66 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 89 In Stock
5MG 73 In Stock
10MG 123 In Stock
25MG 205 In Stock
50MG 362 In Stock
100MG 606 In Stock
200MG 849 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Adomeglivant
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, orally active, small-molecule antagonist of human glucagon receptor with Ki of 6.66 nM.
  • Description
    A potent, selective, orally active, small-molecule antagonist of human glucagon receptor with Ki of 6.66 nM; displays >200-fold selectivity over related receptors; exhibits robust glucose-lowering in response to daily oral administration in an ob/ob mouse model of type 2 diabetes mellitus.Diabetes Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Avpires-Cre+ miceDosage:5 mg/kg Administration:Intraperitoneal injection, 30 minutes prior to CNOResult:Completely abolished the hyperglycaemic action of CNO.
  • Synonyms
    LY-2409021
  • Pathway
    GPCR/G Protein
  • Target
    Glucagon Receptor
  • Recptor
    Glucagon Receptor
  • Research Area
    Metabolic Disease
  • Indication
    Diabetes

Chemical Information

  • CAS Number
    1488363-78-5
  • Formula Weight
    555.6277
  • Molecular Formula
    C32H36F3NO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 5.3 mg/mL
  • SMILES
    O=C(O)CCNC(C1=CC=C([C@@H](OC2=CC(C)=C(C3=CC=C(C(C)(C)C)C=C3)C(C)=C2)CCC(F)(F)F)C=C1)=O
  • Chemical Name
    β-Alanine, N-[4-[(1S)-1-[[4'-(1,1-dimethylethyl)-2,6-dimethyl[1,1'-biphenyl]-4-yl]oxy]-4,4,4-trifluorobutyl]benzoyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kelly RP, et al. Diabetes Obes Metab. 2015 Apr;17(4):414-22. 2. Grover S, et al. BMC Bioinformatics. 2014;15 Suppl 16:S13. 3. Kazda CM, et al. Diabetes Obes Metab. 2017 Aug;19(8):1071-1077.
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