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Pregabalin

CAS No. 148553-50-8

Pregabalin( CI-1008 | S-(+)-3-isobutylgaba )

Catalog No. M12048 CAS No. 148553-50-8

Pregabalin (CI-1008) is a 3-isobutyl derivative of GABA that selectively binds to alpha2delta (A2D) subunit voltage-dependent calcium channels (VDCCs).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Pregabalin
  • Note
    Research use only, not for human use.
  • Brief Description
    Pregabalin (CI-1008) is a 3-isobutyl derivative of GABA that selectively binds to alpha2delta (A2D) subunit voltage-dependent calcium channels (VDCCs).
  • Description
    Pregabalin (CI-1008) is a 3-isobutyl derivative of GABA that selectively binds to alpha2delta (A2D) subunit voltage-dependent calcium channels (VDCCs); prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation.Epilepsy Approved.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    CI-1008 | S-(+)-3-isobutylgaba
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Calcium Channel
  • Research Area
    Neurological Disease
  • Indication
    Epilepsy

Chemical Information

  • CAS Number
    148553-50-8
  • Formula Weight
    159.23
  • Molecular Formula
    C8H17NO2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)C[C@H](CN)CC(O)=O
  • Chemical Name
    (S)-3-(Aminomethyl)-5-methylhexanoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Field MJ, et al. Br J Pharmacol. 1997 Aug;121(8):1513-22. 2. Field MJ, et al. J Pharmacol Exp Ther. 1997 Sep;282(3):1242-6. 3. Eutamene H, et al. J Pharmacol Exp Ther. 2000 Oct;295(1):162-7.
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