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Nef-IN-B9
CAS No. 1473404-51-1
Nef-IN-B9( Nef inhibitor B9 )
Catalog No. M12024 CAS No. 1473404-51-1
Nef-IN-B9 (Nef inhibitor B9) is a small molecule that blocks Nef-dependent Hck activity with IC50 of 2.8 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 240 | In Stock |
|
| 5MG | 217 | In Stock |
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| 10MG | 345 | In Stock |
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| 25MG | 566 | In Stock |
|
| 50MG | 807 | In Stock |
|
| 100MG | 1097 | In Stock |
|
| 200MG | 1479 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNef-IN-B9
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NoteResearch use only, not for human use.
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Brief DescriptionNef-IN-B9 (Nef inhibitor B9) is a small molecule that blocks Nef-dependent Hck activity with IC50 of 2.8 uM.
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DescriptionNef-IN-B9 (Nef inhibitor B9) is a small molecule that blocks Nef-dependent Hck activity with IC50 of 2.8 uM, while the activity against Hck alone is >20 uM; also showes weak activity against other Src-family members with IC50 of >20 uM for c-Src, Lck and Lyn; blocks wild-type HIV-1 replication with IC50 of 100-300 nM, and blocks Nef-mediated SFK activation in HIV-infected cells; binds directly to Nef with Kd of 1.79 nM.
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In VitroHck-IN-1 (compound B9) shows weak activity against other Src-family members in vitro, with IC50 values >20 μM for c-Src, Lck and Lyn. B9 (1 μM; 8 days) completely inhibits Nef-dependent SFK activation at a concentration of 1.0 μM. Hck-IN-1 (0.1, 0.3, 1, 3 μM) also inhibits Nef-mediated enhancement of HIV-1 infectivity in a concentration-dependent manner in the reporter cell line, TZM-bl. Hck-IN-1 inhibits the replication of all eleven HIV-1 Nef chimeras with IC50 values of ~ 300 nM in CEM-T4 cells, demonstrating that the compound is broadly active against HIV replication supported by a wide range of HIV-1 Nef proteins. Western Blot Analysis Cell Line:CEM-T4 cells.Concentration:1 μM.Incubation Time:8 daysResult:Completely inhibited Nef-dependent SFK activation at a concentration of 1.0 μM.
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In Vivo——
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SynonymsNef inhibitor B9
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV
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Research Area——
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Indication——
Chemical Information
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CAS Number1473404-51-1
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Formula Weight402.813
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Molecular FormulaC16H11ClN6O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 12.5 mg/mL (31.03 mM)
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SMILES——
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Chemical Name(E)-4-((3-chlorophenyl)diazenyl)-5-hydroxy-3-(4-nitrophenyl)-1H-pyrazole-1-carbothioamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Emert-Sedlak LA, et al. Chem Biol. 2013 Jan 24;20(1):82-91.
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