Oxolinic acid

Research use only, not for human use.

Oxolinic acid is a potent inhibitor of DNA gyrase and DNA synthesis, lead to DNA cleavage when extracted chromosomes are incubated with sodium dodecyl sulfate.

Oxolinic acid is a potent inhibitor of DNA gyrase and DNA synthesis, lead to DNA cleavage when extracted chromosomes are incubated with sodium dodecyl sulfate.(In Vitro):Oxolinic acid (2-5 ug/mL) inhibits 115 strains of E. coli.Oxolinic acid (0-31 ug/mL) inhibits 94 % of the 44 strains of Proteus mirabilis .Oxolinic acid (>5 ug/mL) inhibits all strains of Strept. Faecalis.Oxolinic acid (>2 ug/mL) causes chromosomal DNA supercoiling to decrease in the two wild-type E. coli K-12 strains tested, DM4100 and NI747.Oxolinic acid reduces chromosomal DNA supercoiling and inhibits RNA synthesis in E. coli. (In Vivo):Oxolinic acid (32 mg/kg; i.p.) induces hyperactivity in mice.

Oxolinic acid (2-5 ug/mL) inhibits 115 strains of E. coli.Oxolinic acid (0-31 ug/mL) inhibits 94 % of the 44 strains of Proteus mirabilis .Oxolinic acid (>5 ug/mL) inhibits all strains of Strept. Faecalis.Oxolinic acid (>2 ug/mL) causes chromosomal DNA supercoiling to decrease in the two wild-type E. coli K-12 strains tested, DM4100 and NI747.Oxolinic acid reduces chromosomal DNA supercoiling and inhibits RNA synthesis in E. coli.

Oxolinic acid (32 mg/kg; i.p.) induces hyperactivity in mice. Animal Model:Male Swiss albino CD1 mice (22-25 g) Dosage:16 mg/kg, 32 mg/kg, 64 mg/kg, 128 mg/kg Administration:Intraperitoneal injection Result:Stimulated the horizontal activity of mice, culminated at the 32 mg/kg dose but disappeared at the highest tested dose, 128 mg/kg.

NSC 110364 | Urinox

GPCR/G Protein

Antibacterial

bacterial DNA gyrase| DNA synthesis| dopamine uptake

Infection

——

14698-29-4

261.24

C13H11NO5

>98% (HPLC)

Water: 0.003mg/L

O=C(C1=CN(CC)C2=CC(OCO3)=C3C=C2C1=O)O

5-Ethyl-8-oxo-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid

(-20℃)

With Ice Pack

≥ 2 years