Cart
sales@molnova.com
Adavivint
CAS No. 1467093-03-3
Adavivint( SM-04690 | SM 04690 | SM04690 )
Catalog No. M12002 CAS No. 1467093-03-3
Adavivint (SM-04690, SM 04690, SM04690) is a novel small molecule Wnt pathway inhibitor with EC50 of 3 nM in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
|
| 5MG | 81 | In Stock |
|
| 10MG | 120 | In Stock |
|
| 25MG | 197 | In Stock |
|
| 50MG | 343 | In Stock |
|
| 100MG | 511 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAdavivint
-
NoteResearch use only, not for human use.
-
Brief DescriptionAdavivint (SM-04690, SM 04690, SM04690) is a novel small molecule Wnt pathway inhibitor with EC50 of 3 nM in vitro.
-
DescriptionAdavivint (SM-04690, SM 04690, SM04690) is a novel small molecule Wnt pathway inhibitor with EC50 of 3 nM in vitro; induces hMSC differentiation into mature, functional chondrocytes and decreases cartilage catabolic marker levels; significantly improves Osteoarthritis Research Society International (OARSI) histology scores and biomarkers in a rodent OA model.Rheumatoid Arthritis Phase 2 Clinical(In Vitro):Adavivint (SM04690) is a potent and selective inhibitor of Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCF/LEF-reporter assay in SW480 colon cancer cells, and shows no effect on SV40 luciferase reporter. Adavivint enhances aggregation of human mesenchymal stem cells (hMSCs) with an EC50 of 10 nM. Adavivint (30 nM) protects chondrocytes from catabolic breakdown in vitro.(In Vivo):Adavivint (0.3 μg) enhances cartilage repair and protection in the rat acute cruciate ligament tear and partial medial meniscectomy osteoarthritis (ACLT + pMMx OA) model.
-
In Vitro——
-
In Vivo——
-
SynonymsSM-04690 | SM 04690 | SM04690
-
PathwayWnt/Notch/Hedgehog
-
TargetWnt/beta/catenin
-
RecptorWnt/beta/catenin
-
Research AreaInflammation/Immunology
-
IndicationRheumatoid Arthritis
Chemical Information
-
CAS Number1467093-03-3
-
Formula Weight505.557
-
Molecular FormulaC29H24FN7O
-
Purity>98% (HPLC)
-
SolubilityDMSO : 25 mg/mL 49.45 mM
-
SMILESCC(C)CC(=O)NC1=CN=CC(=C1)C2=CC3=C(C=C2)NN=C3C4=NC5=C(N4)C=NC=C5C6=CC(=CC=C6)F
-
Chemical NameN-(5-{3-[7-(3-fluorophenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-1H-indazol-5-yl}pyridin-3-yl)-3-methylbutanamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Yazici Y, et al. Osteoarthritis Cartilage. 2017 Jul 13. pii: S1063-4584(17)31085-3.
2. Deshmukh V, et al. Osteoarthritis Cartilage. 2017 Sep 6. pii: S1063-4584(17)31167-6.
molnova catalog
related products
-
Wnt pathway inhibito...
Wnt pathway inhibitor 3 is a potent AC1 inhibitor (IC50: 45 nM) with antiproliferative activity, suitable for studies to ameliorate osteoarthritis in a mouse model of experimental osteoarthritis.
-
FIDAS-3
FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding.?
-
NRX-103094
NRX-103094 is a potent enhancer of the interaction between β-catenin and the homologous E3 ligase SCFβ-TrCP, increasing the affinity of pSer33/Ser37 β-catenin for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM.
