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BM212
CAS No. 146204-42-4
BM212( BM-212 | BM 212 )
Catalog No. M11986 CAS No. 146204-42-4
A novel antitubercular agent that possesses strong inhibitory activity against both Mycobacterium tuberculosis (MIC=0.7-1.5 ug/ml) and some nontuberculosis mycobacteria, inhibits transport activity of MmpL3.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 69 | In Stock |
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| 10MG | 112 | In Stock |
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| 25MG | 181 | In Stock |
|
| 50MG | 266 | In Stock |
|
| 100MG | 387 | In Stock |
|
| 200MG | 551 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBM212
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NoteResearch use only, not for human use.
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Brief DescriptionA novel antitubercular agent that possesses strong inhibitory activity against both Mycobacterium tuberculosis (MIC=0.7-1.5 ug/ml) and some nontuberculosis mycobacteria, inhibits transport activity of MmpL3.
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DescriptionA novel antitubercular agent that possesses strong inhibitory activity against both Mycobacterium tuberculosis (MIC=0.7-1.5 ug/ml) and some nontuberculosis mycobacteria, inhibits transport activity of MmpL3; also has marked activity against several species of yeasts, including Candida albicans and Cryptococcus neoformans, is also highly efficacious against mycobacteria which show resistance to the most common traditional drugs.
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In VitroBM212 (2 μg/mL and 8 μg/mL) leads to major structural changes in the cell of M. abscessus CIP104536T S and R variants and results in the complete loss of the hydrophobic nanodomains observed on S cells but no significantly affect on R cells at dose of 2 μg/mL. BM212 (0.5-10 μg/mL, 7 days) inhibits the activity of Mycobacterium avium in U937 cells in a dose-dependent manner with a MIC of 0.5 μg/mL and 100% inhibition starting at a concentration of 1 μg/mL.
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In Vivo——
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SynonymsBM-212 | BM 212
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorAntibacterial
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number146204-42-4
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Formula Weight414.3707
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Molecular FormulaC23H25Cl2N3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCN1CCN(CC2=C(C)N(C3=CC=C(Cl)C=C3)C(C4=CC=C(Cl)C=C4)=C2)CC1
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Chemical NamePiperazine, 1-[[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl]-4-methyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. La Rosa V, et al. Antimicrob Agents Chemother. 2012 Jan;56(1):324-31.
2. Deidda D, et al. Antimicrob Agents Chemother. 1998 Nov;42(11):3035-7.
3. Li W, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6413-23.
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