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SEMBL
CAS No. 1443448-82-5
SEMBL( SEMBL )
Catalog No. M11881 CAS No. 1443448-82-5
SEMBL is a potent NF-κB inhibitor that inhibits DNA binding of NF-κB component p65.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 68 | Get Quote |
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| 50MG | 305 | Get Quote |
|
| 100MG | 464 | Get Quote |
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| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSEMBL
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NoteResearch use only, not for human use.
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Brief DescriptionSEMBL is a potent NF-κB inhibitor that inhibits DNA binding of NF-κB component p65.
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DescriptionSEMBL is a potent NF-κB inhibitor that inhibits DNA binding of NF-κB component p65; inhibits LPS-induced NF-κB activation, iNOS expression, and inflammatory cytokine secretions; also inhibits NF-κB and cellular invasion in ovarian carcinoma ES-2 cells; enhances stability in aqueous solution compared with (-)-DHMEQ.
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In VitroSEMBL inhibits MMP-2 expression and cellular metastatic activity in ovarian carcinoma cells.SEMBL inhibits the cell-free DNA binding of NF-κB in the ES-2 nuclear extract and inhibits the constitutively activated NF-κB activity in ovarian carcinoma cells.SEMBL inhibits cellular migration, invasion and MMP-2 expression in ovarian carcinoma cells at non-toxic concentrations.
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In Vivo——
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SynonymsSEMBL
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PathwayApoptosis
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TargetNF-κB
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RecptorNF-κB
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Research Area——
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Indication——
Chemical Information
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CAS Number1443448-82-5
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Formula Weight233.223
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Molecular FormulaC12H11NO4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (428.78 mM)
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SMILESC=C([C@H](NC(C1=CC=CC=C1O)=O)CO2)C2=O
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Chemical Name(S)-2-hydroxy-N-(4-methylene-5-oxotetrahydrofuran-3-yl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sidthipong K, et al. Bioorg Med Chem Lett. 2017 Feb 1;27(3):562-566.
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