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HBX-19818
CAS No. 1426944-49-1
HBX-19818( HBX19818 | HBX-19818 | HBX 19818 )
Catalog No. M11802 CAS No. 1426944-49-1
HBX-19818 is a potent, selective USP7 inhibitor with IC50 of 28.1 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 82 | In Stock |
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| 5MG | 73 | In Stock |
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| 10MG | 113 | In Stock |
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| 25MG | 187 | In Stock |
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| 50MG | 261 | In Stock |
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| 100MG | 365 | In Stock |
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| 200MG | 518 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameHBX-19818
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NoteResearch use only, not for human use.
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Brief DescriptionHBX-19818 is a potent, selective USP7 inhibitor with IC50 of 28.1 uM.
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DescriptionHBX-19818 is a potent, selective USP7 inhibitor with IC50 of 28.1 uM; exhibits high selectivity over other USP members, such as USP8, USP5, USP2, and USP20 (IC50 >200 uM), and no activity against UCH-L1, UCH-L3 and SENP1; reduces HCT116 cell proliferation, induces caspase activity and PARP cleavage, and arrests HCT116 cancer cells in G1.
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In Vitro——
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In Vivo——
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SynonymsHBX19818 | HBX-19818 | HBX 19818
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PathwayProteasome/Ubiquitin
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TargetDUB
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RecptorDUB
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1426944-49-1
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Formula Weight421.96
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Molecular FormulaC25H28ClN3O
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Purity>98% (HPLC)
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SolubilityDMSO: 3.5 mg/mL; DMSO: 5.3 mg/mL (Need ultrasonic)
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SMILESO=C(C1=CC2=C(Cl)C3=C(CCCC3)N=C2C=C1)NCCCN(C)CC4=CC=CC=C4
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Chemical Name2-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[3-[methyl(phenylmethyl)amino]propyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Reverdy C, et al. Chem Biol. 2012 Apr 20;19(4):467-77.
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