WS-6( WS6 | WS 6 )

Catalog No. M11760 CAS No. 1421227-53-3

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HNMR

HPLC

MSDS

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Product Name

WS-6
Note

Research use only, not for human use.
Brief Description

A small molecule that can induce proliferation of β cells with EC50 of 0.28 uM.
Description

A small molecule that can induce proliferation of β cells with EC50 of 0.28 uM; promotes β cell growth in vivo, increasing β cell mass and normalizing blood glucose in the RIP-DTA mouse model of β cell ablation; acts by inhibiting IKKε and blocking the ability of EBP1 to suppress E2F-medtiated transcription; also stimulates α cell proliferation in human pancreatic islets.
In Vitro

——
In Vivo

——
Synonyms

WS6 | WS 6
Pathway

Immunology/Inflammation
Target

IκB kinase (IKK)
Recptor

ErbB3-BindingProtein-1(EBP2)|IκBkinase
Research Area

Inflammation/Immunology
Indication

——

CAS Number

1421227-53-3
Formula Weight

568.59
Molecular Formula

C29H31F3N6O3
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C(NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1)CC3=CC=C(OC4=NC=NC(NC(C5CC5)=O)=C4)C=C3
Chemical Name

Benzeneacetamide, 4-[[6-[(cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-

1. Swoboda JG, et al. ACS Chem Biol. 2013 Jul 19;8(7):1407-11. 2. Shen W, et al. J Am Chem Soc. 2013 Feb 6; 135(5):1669-72.

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