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WS-6
CAS No. 1421227-53-3
WS-6( WS6 | WS 6 )
Catalog No. M11760 CAS No. 1421227-53-3
A small molecule that can induce proliferation of β cells with EC50 of 0.28 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 57 | In Stock |
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| 5MG | 46 | In Stock |
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| 10MG | 74 | In Stock |
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| 25MG | 139 | In Stock |
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| 50MG | 220 | In Stock |
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| 100MG | 327 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameWS-6
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NoteResearch use only, not for human use.
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Brief DescriptionA small molecule that can induce proliferation of β cells with EC50 of 0.28 uM.
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DescriptionA small molecule that can induce proliferation of β cells with EC50 of 0.28 uM; promotes β cell growth in vivo, increasing β cell mass and normalizing blood glucose in the RIP-DTA mouse model of β cell ablation; acts by inhibiting IKKε and blocking the ability of EBP1 to suppress E2F-medtiated transcription; also stimulates α cell proliferation in human pancreatic islets.
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In Vitro——
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In Vivo——
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SynonymsWS6 | WS 6
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PathwayImmunology/Inflammation
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TargetIκB kinase (IKK)
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RecptorErbB3-BindingProtein-1(EBP2)|IκBkinase
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number1421227-53-3
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Formula Weight568.59
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Molecular FormulaC29H31F3N6O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1)CC3=CC=C(OC4=NC=NC(NC(C5CC5)=O)=C4)C=C3
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Chemical NameBenzeneacetamide, 4-[[6-[(cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Swoboda JG, et al. ACS Chem Biol. 2013 Jul 19;8(7):1407-11.
2. Shen W, et al. J Am Chem Soc. 2013 Feb 6; 135(5):1669-72.
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