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Home - Products - GPCR/G Protein - Calcium Channel - GV-58

GV-58

CAS No. 1402821-41-3

GV-58( GV58 )

Catalog No. M11683 CAS No. 1402821-41-3

GV-58 is a potent, selective N-Type and P/Q-type Ca2+ Channel agonist with EC50 of 7.2 and 8.8 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 154 In Stock
5MG 140 In Stock
10MG 217 In Stock
25MG 432 In Stock
50MG 611 In Stock
100MG 854 In Stock
200MG Get Quote In Stock
500MG 1702 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    GV-58
  • Note
    Research use only, not for human use.
  • Brief Description
    GV-58 is a potent, selective N-Type and P/Q-type Ca2+ Channel agonist with EC50 of 7.2 and 8.8 uM.
  • Description
    GV-58 is a potent, selective N-Type and P/Q-type Ca2+ Channel agonist with EC50 of 7.2 and 8.8 uM, shows no acitivity for L-type calcium channels (EC50>100 uM); has 20-fold less potent cyclin-dependent kinase antagonist effect; slows deactivation (closing) of the channel, resulting in a large increase in total calcium entry during motor nerve action potential activity; weakens Lambert-Eaton myasthenic syndrome-model neuromuscular synapses in a passive transfer mouse model of Lambert-Eaton myasthenic syndrome.
  • In Vitro
    GV-58 (50 μM; 30 min) restores function in LEMS passive transfer neuromuscular junction. Cell Viability Assay Cell Line:Upper arm muscle isolated from LEMS mice Concentration:50 μM Incubation Time:30 min Result:Increased the mEPP frequency from 3.27 s?1 in vehicle controls to 10.45 s?1. Showed a slight facilitation followed by depression to ～94% at the final EPP in the train.
  • In Vivo
    ——
  • Synonyms
    GV58
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Calcium Channel
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    1402821-41-3
  • Formula Weight
    374.5036
  • Molecular Formula
    C18H26N6OS
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CCCN1C=NC2=C(N=C(N=C21)NC(CC)CO)NCC3=CC=C(S3)C
  • Chemical Name
    1-Butanol, 2-[[6-[[(5-methyl-2-thienyl)methyl]amino]-9-propyl-9H-purin-2-yl]amino]-, (2R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tarr TB, et al. Ann N Y Acad Sci. 2012 Dec;1275:85-91. 2. Tarr TB, et al. J Neurosci. 2013 Jun 19;33(25):10559-67. 3. Tarr TB, et al. J Physiol. 2014 Aug 15;592(16):3687-96. 4. Liang M, et al. ACS Med Chem Lett. 2012 Oct 1;3(12):985-90.
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