JAK-IN-35( —— )

Catalog No. M11669 CAS No. 1400687-19-5

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Product Name

JAK-IN-35
Note

Research use only, not for human use.
Brief Description

JAK-IN-35 is a potent and efficacious dual JAK1/JAK3 inhibitor with IC50 of 0.9/1.9 nM.
Description

JAK-IN-35 is a potent and efficacious dual JAK1/JAK3 inhibitor with IC50 of 0.9/1.9 nM; shows weak activity against TYK2 and JAK2 (IC50=25 nM and15 nM respectively), also inhibits both ROCK1 (IC50=95 nM) and ROCK2 (IC50=43 nM); inhibits JAK1/3 mediated ex vivo processes in the mouse PD model (EC50 67 ± 13 nM); shows potential cardiovascular liabilities, specifically, QT interval prolongation.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Angiogenesis
Target

JAK
Recptor

JAK
Research Area

Inflammation/Immunology
Indication

——

CAS Number

1400687-19-5
Formula Weight

408.506
Molecular Formula

C22H28N6O2
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1(C(CCC1(C)N)NC2=C(C=NN3C2=CC(=C3)C4=CN=C(C=C4)OC)C(=O)N)C
Chemical Name

4-(((1R,3S)-3-amino-2,2,3-trimethylcyclopentyl)amino)-6-(6-methoxypyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide

1. Hynes J Jr, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3101-3106.

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