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MFA-1
CAS No. 139755-30-9
MFA-1( Merck FXR agonist 1 )
Catalog No. M11658 CAS No. 139755-30-9
MFA-1 (Merck FXR agonist 1) is a potent, synthetic FXR agonist with EC50 of 16.9 nM in coactivator recruitment assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameMFA-1
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NoteResearch use only, not for human use.
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Brief DescriptionMFA-1 (Merck FXR agonist 1) is a potent, synthetic FXR agonist with EC50 of 16.9 nM in coactivator recruitment assays.
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DescriptionMFA-1 (Merck FXR agonist 1) is a potent, synthetic FXR agonist with EC50 of 16.9 nM in coactivator recruitment assays, displays 500-fold more potent than CDCA; displays an unexpected mode of binding and activation to FXR.
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In Vitro——
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In Vivo——
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SynonymsMerck FXR agonist 1
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PathwayMetabolic Enzyme/Protease
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TargetFXR
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RecptorFXR
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Research Area——
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Indication——
Chemical Information
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CAS Number139755-30-9
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Formula Weight420.549
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Molecular FormulaC27H32O4
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name17beta-(4-hydroxybenzoyl)androsta-3,5-diene-3-carboxylic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Soisson SM, et al. Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5337-42.
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