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JD-5037
CAS No. 1392116-14-1
JD-5037( JD 5037 | JD5037 )
Catalog No. M11626 CAS No. 1392116-14-1
A selective, peripherally restricted cannabinoid-1(CB1) receptor blocker with IC50 of 1.5 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 103 | In Stock |
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| 2MG | 50 | In Stock |
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| 5MG | 83 | In Stock |
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| 10MG | 136 | In Stock |
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| 25MG | 246 | In Stock |
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| 50MG | 362 | In Stock |
|
| 100MG | 538 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJD-5037
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NoteResearch use only, not for human use.
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Brief DescriptionA selective, peripherally restricted cannabinoid-1(CB1) receptor blocker with IC50 of 1.5 nM.
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DescriptionA selective, peripherally restricted cannabinoid-1(CB1) receptor blocker with IC50 of 1.5 nM; shows no effect on CB2 (>10 uM); equieffective with its brain-penetrant parent compound in reducing appetite, body weight, hepatic steatosis, and insulin resistance, even though it does not occupy central CB1R or induce related behaviors.
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In Vitro——
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In Vivo——
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SynonymsJD 5037 | JD5037
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PathwayGPCR/G Protein
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TargetCannabinoid Receptor
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RecptorCB1R
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Research AreaMetabolic Disease
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Indication——
Chemical Information
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CAS Number1392116-14-1
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Formula Weight572.506
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Molecular FormulaC27H27Cl2N5O3S
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM
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SMILESCC(C)[C@@H](C(N)=O)/N=C(N1N=C(C2=CC=C(Cl)C=C2)[C@@H](C3=CC=CC=C3)C1)/NS(=O)(C4=CC=C(Cl)C=C4)=O
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Chemical NameButanamide, 2-[[[(4S)-3-(4-chlorophenyl)-4,5-dihydro-4-phenyl-1H-pyrazol-1-yl][[(4-chlorophenyl)sulfonyl]amino]methylene]amino]-3-methyl-, (2S)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chorvat RJ, et al. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6173-80.
2. Tam J, et al. Cell Metab. 2012 Aug 8;16(2):167-79.
3. Knani I, et al. Mol Metab. 2016 Oct 22;5(12):1187-1199.
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