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DMJ-I-228

CAS No. 1374035-59-2

DMJ-I-228( +)-DMJ-I-228 )

Catalog No. M11542 CAS No. 1374035-59-2

A small molecule CD4-mimetic that binds gp120 and blocks CD4 binding, inhibits HIV-1 entry with IC50 of 86.9 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DMJ-I-228
  • Note
    Research use only, not for human use.
  • Brief Description
    A small molecule CD4-mimetic that binds gp120 and blocks CD4 binding, inhibits HIV-1 entry with IC50 of 86.9 uM.
  • Description
    A small molecule CD4-mimetic that binds gp120 and blocks CD4 binding, inhibits HIV-1 entry with IC50 of 86.9 uM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    +)-DMJ-I-228
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1374035-59-2
  • Formula Weight
    435.84
  • Molecular Formula
    C19H19ClFN5O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NC1=CC=C(Cl)C(F)=C1)C(N[C@@H]2[C@@H](NC(N)=N)CC3=C2C=CC=C3)=O.O=CO
  • Chemical Name
    N1-(4-chloro-3-fluorophenyl)-N2-((1S,2S)-2-guanidino-2,3-dihydro-1H-inden-1-yl)oxalamide formate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Madani N, et al. Structure. 2008 Nov 12; 16(11):1689-701. 2. Richard J, et al. Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2687-94. 3. LaLonde JM, et al. J Med Chem. 2012 May 10;55(9):4382-96.
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