GNE-293( GNE293 )

Catalog No. M11451 CAS No. 1354955-67-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GNE-293
Note

Research use only, not for human use.
Brief Description

GNE-293 is a potent and selective PI3Kδ inhibitor with Ki of 0.47 nM, displays 256, 420, 219-fold selectivity over PI3Kα, PI3Kβ, PI3Kγ, respectively.
Description

GNE-293 is a potent and selective PI3Kδ inhibitor with Ki of 0.47 nM, displays 256, 420, 219-fold selectivity over PI3Kα, PI3Kβ, PI3Kγ, respectively; exhibits excellent potency in human whole blood (HWB) assay (CD69 HWB IC50=4.38 nM); possesses favorable pharmacokinetic properties and orally bioavailable.
In Vitro

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In Vivo

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Synonyms

GNE293
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3K
Research Area

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Indication

——

CAS Number

1354955-67-1
Formula Weight

580.708
Molecular Formula

C28H36N8O4S
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(C)C1=NC(C=CC=C2)=C2N1C3=NC4=C(N=C(OC5CN(C6CCS(CC6)(=O)=O)C5)N4C)C(N7CCOCC7)=N3
Chemical Name

4-(3-((2-(2-isopropyl-1H-benzo[d]imidazol-1-yl)-9-methyl-6-morpholino-9H-purin-8-yl)oxy)azetidin-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide

1. Safina BS, et al. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4953-9.

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