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Naloxegol oxalate
CAS No. 1354744-91-4
Naloxegol oxalate( AZ 13337019 | NKTR-118 )
Catalog No. M11448 CAS No. 1354744-91-4
Naloxegol (NKTR-118 and AZ-13337019), is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 63 | In Stock |
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| 5MG | 38 | In Stock |
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| 10MG | 53 | In Stock |
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| 25MG | 87 | In Stock |
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| 50MG | 124 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameNaloxegol oxalate
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NoteResearch use only, not for human use.
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Brief DescriptionNaloxegol (NKTR-118 and AZ-13337019), is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation.
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DescriptionNaloxegol (NKTR-118 and AZ-13337019), is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation. It was approved in 2014 in adult patients with chronic, non-Y pain. Chemically, naloxegol is a pegylated (polyethylene glycol-modified) derivative of α-naloxol. Specifically, the 5-α-hydroxyl group of α-naloxol is connected via an ether linkage to the free hydroxyl group of a monomethoxy-terminated n=7 oligomer of PEG.
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In Vitro——
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In Vivo——
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SynonymsAZ 13337019 | NKTR-118
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PathwayMetabolic Enzyme/Protease
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TargetP450
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RecptorCYP3A
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number1354744-91-4
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Formula Weight741.828
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Molecular FormulaC36H55NO15
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Purity>98% (HPLC)
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SolubilityDMSO：≥ 40 mg/mL
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SMILESCOCCOCCOCCOCCOCCOCCOCCO[C@H]1CC[C@]2([C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)O)CCN3CC=C)O.C(=O)(C(=O)O)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Bui K, et al. J Clin Pharmacol. 2016 Aug;56(8):1019-27.
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