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Pregnenolone Carbonitrile

CAS No. 1434-54-4

Pregnenolone Carbonitrile( 5-Pregnen-3β-ol-20-one-16α-carbonitrile | Pregnenolone 16α-carbonitrile? )

Catalog No. M27472 CAS No. 1434-54-4

Pregnenolone Carbonitrile is an activator of rodent-PXR and induces the expression of CYP3A.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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1 mL x 10 mM in DMSO 42 In Stock
5MG 47 In Stock
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Biological Information

  • Product Name
    Pregnenolone Carbonitrile
  • Note
    Research use only, not for human use.
  • Brief Description
    Pregnenolone Carbonitrile is an activator of rodent-PXR and induces the expression of CYP3A.
  • Description
    Pregnenolone Carbonitrile is an activator of rodent-PXR and induces the expression of CYP3A.(In Vitro):Pregnenolone Carbonitrile is hepatoprotective by increasing resistance to subsequent stressful insults.(In Vivo):In WT mice, Pregnenolone Carbonitrile (40 mg/kg/day; i.p.) induces the expression of CYP3A11 and CYP2B10 at the mRNA, protein, and enzymatic levels. In adult female Sprague-Dawley rats, Pregnenolone Carbonitrile (100 mg/kg; i.p.) induces the expression of CYP3A mRNA. In male Sprague-Dawley rats, Pregnenolone Carbonitrile (35 mg/kg; gavage) increase in Pgp expression.
  • In Vitro
    ——
  • In Vivo
    Animal Model:WT and Pxr-/- mice Dosage:40 mg/kg Administration:IP; per day for two days Result:Induced the expression of Cyp3a11 and Cyp2b10 at the mRNA, protein, and enzymatic levels in WT mice.Had little effect on the expression of Cyp3a11 in Pxr-/- mice
  • Synonyms
    5-Pregnen-3β-ol-20-one-16α-carbonitrile | Pregnenolone 16α-carbonitrile?
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    P450
  • Recptor
    enoyl-acyl carrier protein reductase (FabI)|S. aureus
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1434-54-4
  • Formula Weight
    341.49
  • Molecular Formula
    C22H31NO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 20 mg/mL (58.57 mM)
  • SMILES
    C[C@@]12[C@]([C@]3([C@](CC1)([C@]4(C)C(=CC3)C[C@@H](O)CC4)[H])[H])(C[C@@H](C#N)[C@@H]2C(C)=O)[H]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kim BY, Sohn YT. Solid state of CG-400549, a novel FabI inhibitor: characterization, dissolution, transformation. Arch Pharm Res. 2011 May;34(5):775-9.
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