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OSU-2S
CAS No. 1351056-65-9
OSU-2S( OSU 2S )
Catalog No. M11419 CAS No. 1351056-65-9
A non-immunosuppressive FTY720 analogue, PKCδ activator with higher antiproliferative potency.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameOSU-2S
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NoteResearch use only, not for human use.
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Brief DescriptionA non-immunosuppressive FTY720 analogue, PKCδ activator with higher antiproliferative potency.
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DescriptionA non-immunosuppressive FTY720 analogue, PKCδ activator with higher antiproliferative potency with IC50 of 2.4, 2.4, and 3.5 uM in Huh7, Hep3B, and PLC5 cells, respectively; exhibited higher in vitro antiproliferative efficacy relative to FTY720 against HCC cells without cytotoxicity in normal hepatocytes, although devoid of S1P1 receptor activity; induces caspase-dependent apoptosis through ROS-dependent PKCδ activation in HCC tumor cells.
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In VitroCell Proliferation AssayCell Line:Hep3B, Huh7, PLC-5, HepG2 cells Concentration:0-10 μM Incubation Time:48 h Result:Showed anti-proliferative effects with IC50s of 2.53, 2.41, 3.96, 1.84 μM for Hep3B, Huh7, PLC-5, HepG2 cells, respectively.Western Blot Analysis Cell Line:Hep3B cells Concentration:1.25, 2.5 μM combinated with sorafenib (2.5, 5 μM)Incubation Time:48 h Result:Decreased the expression of ERK1/2 phosphorylation, increased the expression of PKCδ (38 kDa) when sorafenib/OSU-2S combination.
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In VivoAnimal Model:CD2F1 mice (Hep3B tumor xenograft models)Dosage:5, 10 mg/kg Administration:I.p.; once daily for 42 days Result:Exhibited a higher tumor-suppressive potency, achieving 80% reduction in bioluminescence at the end of treatment.
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SynonymsOSU 2S
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PathwayAngiogenesis
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TargetPKC
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RecptorPKC
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Research Area——
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Indication——
Chemical Information
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CAS Number1351056-65-9
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Formula Weight335.532
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Molecular FormulaC21H37NO2
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Purity>98% (HPLC)
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Solubility——
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SMILESCCC[C@@](CCC1=CC=C(OCCCCCC(C)C)C=C1)(N)CO.[H]Cl
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Chemical Name(S)-2-amino-2-(4-[(6-methylheptyl)-oxy]phenethyl)pentan-1-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Bryostatin 1
Bryostatin 1 (NSC 339555) is a macrocyclic lactone derived from a marine invertebrate, fuctions as an activator of PKC with high binding affinity (Ki=1.35 nM).
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PKC β pseudosubstrat...
Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM). Consists of amino acids 19 - 31 of PKC pseudosubstrate domain linked by a disulphide bridge to a cell permeabilisation Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide.
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LY379196
LY379196 is a highly specific PKCβ inhibitor with IC50 of 30-50 nM for PKCβI and PKCβII.
