GF109203X( BIM I | GF 109203X | G? 6850 )

Catalog No. M11312 CAS No. 133052-90-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GF109203X
Note

Research use only, not for human use.
Brief Description

GF109203X is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ, respectively.
Description

GF109203X is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor.
In Vitro

——
In Vivo

Animal Model: Quinpirole-treated shrews Dosage:0-20 mg/kg Administration:i.p.Result:Reduced the mean frequency of Quinpirole-induced vomiting.Blocked Quinpirole-mediated ERK1/2 phosphorylation in shrew brainstems.
Synonyms

BIM I | GF 109203X | G? 6850
Pathway

Angiogenesis
Target

PDGFR
Recptor

PDGFR| PKCα| PKCβ1| PKCβ2| PKCγ
Research Area

Metabolic Disease
Indication

——

CAS Number

133052-90-1
Formula Weight

412.48
Molecular Formula

C25H24N4O2
Purity

>98% (HPLC)
Solubility

DMSO:82 mg/mL (198.79 mM); Ethanol:<1 mg/mL (<1 mM); Water:<1 mg/mL (<1 mM)
SMILES

O=C(C(C1=CN(CCCN(C)C)C2=C1C=CC=C2)=C3C4=CNC5=C4C=CC=C5)NC3=O.
Chemical Name

3-(1-(3-(dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

1. Toullec D, et al. J Biol Chem. 1991, 266(24), 15771-15781.

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