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SU16f

CAS No. 251356-45-3

SU16f( SU 16F | 3-substituted indolin-2-one 16f | SU-16F )

Catalog No. M26828 CAS No. 251356-45-3

SU16f is a potent and selective PDGFRβ inhibitor (IC50s: 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    SU16f
  • Note
    Research use only, not for human use.
  • Brief Description
    SU16f is a potent and selective PDGFRβ inhibitor (IC50s: 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively).
  • Description
    SU16f is a potent and selective PDGFRβ inhibitor (IC50s: 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively). Neutralization of PDGFRβ receptor by SU16f blocks the promoting role of GC-MSCs conditioned medium in gastric cancer cell proliferation and migration.(In Vitro):SU16f (20 μM; for 8 hours) significantly abolishes PDGFRβ activation in SGC-7901 by GC-MSC-CM. SU16f (20 μM; for 8 hours) pretreatment inhibits the promoting role of GC-MSC-CM in SGC-7901 cell proliferation. SU16f pretreatment leads to downregulation of p-AKT, Bcl-xl, and Bcl-2 levels and upregulation of Bax expression in SGC-7901 cells by GC-MSC-CM. SU16f pretreatment causes the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA .
  • In Vitro
    SU16f (20 μM; for 8 hours) pretreatment inhibits the promoting role of GC-MSC-CM in SGC-7901 cell proliferation.SU16f (20 μM; for 8 hours) significantly abolishes PDGFRβ activation in SGC-7901 by GC-MSC-CM. SU16f pretreatment results in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA. SU16f pretreatment leads to downregulation of p-AKT, Bcl-xl, and Bcl-2 levels and upregulation of Bax expression in SGC-7901 cells by GC-MSC-CM .Cell Proliferation Assay Cell Line:SGC-7901 cells in GC-MSC/SGC-7901 co-culture system Concentration:20 μM Incubation Time:8 hours Result:Inhibited the promoting role of GC-MSC-CM in SGC-7901 cell proliferation. Western Blot Analysis Cell Line:SGC-7901 cells Concentration:20 μM Incubation Time:8 hours Result:Significantly abolished PDGFRβ activation in SGC-7901 by GC-MSC-CM, and resulted in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA.
  • In Vivo
    ——
  • Synonyms
    SU 16F | 3-substituted indolin-2-one 16f | SU-16F
  • Pathway
    Angiogenesis
  • Target
    PDGFR
  • Recptor
    MDM-2/p53
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    251356-45-3
  • Formula Weight
    386.451
  • Molecular Formula
    C24H22N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (129.39 mM)
  • SMILES
    Cc1[nH]c(\C=C2/C(=O)Nc3cc(ccc23)-c2ccccc2)c(C)c1CCC(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chattopadhyay A, et al. Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell. Sci Rep. 2016;6:23732.
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