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FPL 62064
CAS No. 103141-09-9
FPL 62064( —— )
Catalog No. M21617 CAS No. 103141-09-9
FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 67 | In Stock |
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| 2MG | 30 | In Stock |
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| 5MG | 48 | In Stock |
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| 10MG | 79 | In Stock |
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| 25MG | 139 | In Stock |
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| 50MG | 206 | In Stock |
|
| 100MG | 307 | In Stock |
|
| 200MG | 429 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameFPL 62064
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NoteResearch use only, not for human use.
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Brief DescriptionFPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase respectively).
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DescriptionFPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase respectively).
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In VitroFPL 62064 inhibits both 5-1ipoxygenase (IC50 of 3.5 μM for RBL-1 cytosolic 5-1ipoxygenase) and prostaglandin synthetase (IC50 of 3.1 μM for seminal vesicle prostaglandin synthetase ) with equal facility in the isolated enzyme screens. However in the intact RBL-I cell prostaglandin synthetase (IC50 of 3.6 μM) is more readily inhibited by FPL 62064 than is 5-1ipoxygenase (IC50 of 31 μM). This difference in sensitivity is not reflected in the mouse macrophage where the IC50s for leukotriene (IC50 of 0.72 μM) and prostaglandin (IC50 of 0.43 μM) production are similar.
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In VivoFPL 62064 (5-20 mg/kg; intraperitoneal injection; female LACA mice) treatment inhibits peritoneal inflammation induced by immune-complex. Animal Model:Female LACA mice (20-30 g) injected with immune complex.Dosage:5 mg/kg, 10 mg/kg, 20 mg/kg Administration:Intraperitoneal injection Result:Produced a dose-related inhibition of dye extravasation, leukotriene C4 (LTC4) and prostaglandin E2 (PGE2) formation.
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptorCOX|5-LOX
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Research Area——
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Indication——
Chemical Information
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CAS Number103141-09-9
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Formula Weight265.31
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Molecular FormulaC16H15N3O
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Purity>98% (HPLC)
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SolubilityDMSO:250 mg/mL (942.29 mM; Need ultrasonic)
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SMILESCOc1ccc(Nc2ccn(n2)-c2ccccc2)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Blackham A et al. FPL 62064 a topically active 5-lipoxygenase/cyclooxygenase inhibitor. Agents Actions. 1990 Jun;30(3-4):432-42.
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