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Diphenylpyraline hydrochloride
CAS No. 132-18-3
Diphenylpyraline hydrochloride( Diphenylpyraline hydrochloride | Diafen hydrochloride | Diaphen )
Catalog No. M11298 CAS No. 132-18-3
Diphenylpyraline Hcl is a first-generation antihistamine with anticholinergic effects, acts as a dopamine reuptake inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 28 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDiphenylpyraline hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionDiphenylpyraline Hcl is a first-generation antihistamine with anticholinergic effects, acts as a dopamine reuptake inhibitor.
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DescriptionDiphenylpyraline Hcl is a first-generation antihistamine with anticholinergic effects, acts as a dopamine reuptake inhibitor, shows to be useful in the treatment of Parkinsonism.(In Vitro):Diphenylpyraline hydrochloride (10 μM) markedly inhibits dopamine uptakein mouse nucleus accumbens slices.(In Vivo):Diphenylpyraline hydrochloride (intraperitoneal injection; 5-10 mg/kg) elevates extracellular dopamine levels (~200%) in mouse nucleus accumbens and induces locomotor activation in mice.
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In VitroDiphenylpyraline hydrochloride (10 μM) markedly inhibits dopamine uptakein mouse nucleus accumbens slices.
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In Vivo——
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SynonymsDiphenylpyraline hydrochloride | Diafen hydrochloride | Diaphen
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PathwayGPCR/G Protein
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TargetHistamine Receptor
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RecptorH1 receptor
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number132-18-3
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Formula Weight317.85
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Molecular FormulaC19H23NO·HCl
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Purity>98% (HPLC)
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SolubilitySoluble in DMSO
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SMILESCN1CCC(OC(C2=CC=CC=C2)C3=CC=CC=C3)CC1.[H]Cl
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Chemical NamePiperidine, 4-(diphenylmethoxy)-1-methyl-, hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lapa GB, et al. Eur J Pharmacol. 2005, 506(3):237-40.
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