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EMA401

CAS No. 1316755-16-4

EMA401( EMA 401 | EMA-401 | Olodanrigan )

Catalog No. M11283 CAS No. 1316755-16-4

EMA401 (Olodanrigan) is a potent, highly selective angiotensin II type 2 receptor (AT2R) antagonist, inhibits capsaicin responses in cultured neurons of human and rat DRG with IC50 of 10 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 38 In Stock
5MG 33 In Stock
10MG 51 In Stock
25MG 103 In Stock
50MG 165 In Stock
100MG 245 In Stock
200MG 365 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    EMA401
  • Note
    Research use only, not for human use.
  • Brief Description
    EMA401 (Olodanrigan) is a potent, highly selective angiotensin II type 2 receptor (AT2R) antagonist, inhibits capsaicin responses in cultured neurons of human and rat DRG with IC50 of 10 nM.
  • Description
    EMA401 (Olodanrigan) is a potent, highly selective angiotensin II type 2 receptor (AT2R) antagonist, inhibits capsaicin responses in cultured neurons of human and rat DRG with IC50 of 10 nM; EMA401 is a novel peripherally-restricted analgesic, may act on paracrine/autocrine mechanisms at peripheral nerve terminals, or intracrine mechanisms, to reduce neuropathic pain signalling in AngII/NGF/TRPV1-convergent pathways.Pain Phase 2 Clinical(In Vivo):EMA401 (10 mg/kg; p.o.) results in a significant attenuation of theta power and increase in paw withdrawal latencies (PWL) in rats at day 14 after chronic constriction injury (CCI).
  • In Vitro
    ——
  • In Vivo
    EMA401 (10?mg/kg; p.o.) results in a significant attenuation of theta power and increase in paw withdrawal latencies (PWL) in rats at day 14 after chronic constriction injury (CCI).
  • Synonyms
    EMA 401 | EMA-401 | Olodanrigan
  • Pathway
    GPCR/G Protein
  • Target
    Angiotensin Receptor
  • Recptor
    angiotensinIIreceptor
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    1316755-16-4
  • Formula Weight
    507.5764
  • Molecular Formula
    C32H29NO5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 34 mg/mL
  • SMILES
    COC1=C(C2=C(CN(C(C2)C(=O)O)C(=O)C(C3=CC=CC=C3)C4=CC=CC=C4)C=C1)OCC5=CC=CC=C5
  • Chemical Name
    3-Isoquinolinecarboxylic acid, 2-(2,2-diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-, (3S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Anand U, et al. Eur J Pain. 2013 Aug;17(7):1012-26. 2. Smith MT, et al. Pain Med. 2013 May;14(5):692-705. 3. Rice ASC, et al. Lancet. 2014 May 10;383(9929):1637-1647. 4. Anand U, et al. Mol Pain. 2015 Jun 26;11:38.
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