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PD 123319
CAS No. 130663-39-7
PD 123319( PD123319 | PD-123319 | (S)-(+)-PD 123319 )
Catalog No. M11225 CAS No. 130663-39-7
A potent, selective, non-peptide AT2 receptor with IC50 of 34 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 90 | In Stock |
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| 2MG | 36 | In Stock |
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| 5MG | 70 | In Stock |
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| 10MG | 107 | In Stock |
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| 25MG | 219 | In Stock |
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| 50MG | 279 | In Stock |
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| 100MG | 363 | In Stock |
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| 200MG | 516 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePD 123319
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, non-peptide AT2 receptor with IC50 of 34 nM.
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DescriptionA potent, selective, non-peptide AT2 receptor with IC50 of 34 nM.Heart Failure Discontinued.
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In VitroPD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues.?125I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC50 of 92.9 nM) for DuP-753. PD-123319 does not have any effect on?125I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC50 around 10 microM).?
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In Vivo——
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SynonymsPD123319 | PD-123319 | (S)-(+)-PD 123319
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PathwayGPCR/G Protein
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TargetAngiotensin Receptor
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RecptorAT2receptor
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number130663-39-7
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Formula Weight508.6108
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Molecular FormulaC31H32N4O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC1=C(C=CC(=C1)CN2C=NC3=C2C[C@H](N(C3)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C(=O)O)N(C)C
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Chemical Name1H-Imidazo[4,5-c]pyridine-6-carboxylic acid, 1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-, (6S)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Blankley CJ, et al. J Med Chem. 1991 Nov;34(11):3248-60.
2. Keiser JA, et al. J Pharmacol Exp Ther. 1992 Sep;262(3):1154-60.
3. Macari D, et al. Eur J Pharmacol. 1993 Nov 2;249(1):85-93.
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