H4 Receptor antagonist 1( —— )

Catalog No. M20493 CAS No. 848217-00-5

H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist with an IC50 of 19 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	38	In Stock
5MG	34	In Stock
10MG	53	In Stock
25MG	106	In Stock
50MG	179	In Stock
100MG	259	In Stock
200MG	365	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

H4 Receptor antagonist 1
Note

Research use only, not for human use.
Brief Description

H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist with an IC50 of 19 nM.
Description

H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist with an IC50 of 19 nM.
In Vitro

H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM.
In Vivo

H4 Receptor antagonist 1 indicates that metabolic stability in rat microsomes is very low with only 1% parent compound remaining after 10 min incubation.
Synonyms

——
Pathway

GPCR/G Protein
Target

Histamine Receptor
Recptor

H4 receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

848217-00-5
Formula Weight

316.78
Molecular Formula

C16H17ClN4O
Purity

>98% (HPLC)
Solubility

DMSO:10 mg/mL (31.57 mM)
SMILES

CN1CCN(CC1)c1nc(C)nc2c3cc(Cl)ccc3oc12
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Cramp S Dyke H J Higgs C et al. Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists[J]. Bioorganic & Medicinal Chemistry Letters 2010 20(8):2516-2519.

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