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PI3K-IN-8q

CAS No. 1280204-67-2

PI3K-IN-8q( —— )

Catalog No. M11155 CAS No. 1280204-67-2

PI3K-IN-8q is a potent, selective dual p110α/p110δ inhibitor with Ki app of 3.3/8.36 nM respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PI3K-IN-8q
  • Note
    Research use only, not for human use.
  • Brief Description
    PI3K-IN-8q is a potent, selective dual p110α/p110δ inhibitor with Ki app of 3.3/8.36 nM respectively.
  • Description
    PI3K-IN-8q is a potent, selective dual p110α/p110δ inhibitor with Ki app of 3.3/8.36 nM respectively; exhibits high selectivity over p110α and p110β (Ki>490 nM); inhibits p-Akt with EC50 of 50 nM, and p110α with IC50 of 0.5 nM; has promising in vivo PK data; orally bioavailable.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PI3K
  • Recptor
    PI3K
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1280204-67-2
  • Formula Weight
    446.49
  • Molecular Formula
    C23H23FN8O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    5-(2-(4-fluorophenyl)-9-morpholino-1,2,3,4-tetrahydropyrido[3',4':4,5]imidazo[1,2-a]pyrazin-7-yl)pyrimidin-2-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Martínez González S, et al. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2536-2543.
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