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PQ-912
CAS No. 1276021-65-8
PQ-912( PQ 912 | PQ912 )
Catalog No. M11147 CAS No. 1276021-65-8
PQ-912 (PQ 912, PQ912) is a potent glutaminyl cyclase (QC) inhibitor that inhibits human, rat, and mouse QC with Ki of 20-65 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePQ-912
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NoteResearch use only, not for human use.
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Brief DescriptionPQ-912 (PQ 912, PQ912) is a potent glutaminyl cyclase (QC) inhibitor that inhibits human, rat, and mouse QC with Ki of 20-65 nM.
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DescriptionPQ-912 (PQ 912, PQ912) is a potent glutaminyl cyclase (QC) inhibitor that inhibits human, rat, and mouse QC with Ki of 20-65 nM; shows a favourable profile of the compound for QC engagement coupled to a reduction of pE-Aβ and behavioural improvementsthe first in class inhibitor of glutaminyl cyclases currently being in clinical development for Alzheimer's disease.Alzheimer Disease Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsPQ 912 | PQ912
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PathwayOthers
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TargetOther Targets
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RecptorOther Targets
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Research AreaNeurological Disease
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IndicationAlzheimer Disease
Chemical Information
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CAS Number1276021-65-8
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Formula Weight336.395
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Molecular FormulaC19H20N4O2
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Purity>98% (HPLC)
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SolubilityDMSO : 200 mg/mL 594.55 mM
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SMILESO=C1NC[C@H](C2=CC=C(OCCC)C=C2)N1C3=CC=C4C(NC=N4)=C3
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Chemical Name(S)-1-(1H-benzo[d]imidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hoffmann T, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):119-130.
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