BMS 986158( BMS986158 )

Catalog No. M12735 CAS No. 1800340-40-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

BMS 986158
Note

Research use only, not for human use.
Brief Description

BMS-986158 (BMS986158) is a potent and selective BET inhibitor.
Description

BMS-986158 (BMS986158) is a potent and selective BET inhibitor, disrupts chromatin remodeling and prevents the expression of certain growth-promoting genes, resulting in an inhibition of tumor cell growth.Solid Tumors Phase 2 Clinical.
In Vitro

BMS-986158 is an inhibitor of the bromodomain (BRD) and extra-terminal domain (BET) family of proteins, with potential antineoplastic activity. Upon administration, the BET inhibitor BMS-986158 binds to the acetyl-lysine binding site in the BRD of BET proteins, thereby preventing the interaction between BET proteins and acetylated histones. This disrupts chromatin remodeling and prevents the expression of certain growth-promoting genes, resulting in an inhibition of tumor cell growth.
In Vivo

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Synonyms

BMS986158
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

Cancer
Indication

Solid Tumors

CAS Number

1800340-40-2
Formula Weight

495.627
Molecular Formula

C30H33N5O2
Purity

>98% (HPLC)
Solubility

DMSO : 1 mg/mL 2.02 mM
SMILES

OC(C)(C)C1=CC=C2C(N([C@H](C3=CC=CC=C3)C4CCOCC4)C5=C2N=CC(C6=C(C)N=NN6C)=C5)=C1
Chemical Name

(S)-2-(3-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-5-(phenyl(tetrahydro-2H-pyran-4-yl)methyl)-5H-pyrido[3,2-b]indol-7-yl)propan-2-ol